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First published online 23 May 2007
doi: 10.1242/dev.02863

Development 134, 2415-2424 (2007)
Published by The Company of Biologists 2007
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Evolution of the dorsal-ventral patterning network in the mosquito, Anopheles gambiae

Yury Goltsev1, Naoyuki Fuse2, Manfred Frasch3, Robert P. Zinzen1, Gregory Lanzaro4 and Mike Levine1,*

1 Department MCB, Division of GGD, Center for Integrative Genomics, University of California, Berkeley, CA 94720, USA.
2 Department of Developmental Genetics, National Institute of Genetics, 1111 Yata, Mishima 411-8540, Japan.
3 Brookdale Department of Molecular, Cell and Developmental Biology, Box 1020, Mount Sinai School of Medicine, New York, NY 10029, USA.
4 Department of Entomology, University of California, Davis, CA 95616, USA.

* Author for correspondence (e-mail: mlevine{at}berkeley.edu)

Accepted 3 April 2007

The dorsal-ventral patterning of the Drosophila embryo is controlled by a well-defined gene regulation network. We wish to understand how changes in this network produce evolutionary diversity in insect gastrulation. The present study focuses on the dorsal ectoderm in two highly divergent dipterans, the fruitfly Drosophila melanogaster and the mosquito Anopheles gambiae. In D. melanogaster, the dorsal midline of the dorsal ectoderm forms a single extra-embryonic membrane, the amnioserosa. In A. gambiae, an expanded domain forms two distinct extra-embryonic tissues, the amnion and serosa. The analysis of approximately 20 different dorsal-ventral patterning genes suggests that the initial specification of the mesoderm and ventral neurogenic ectoderm is highly conserved in flies and mosquitoes. By contrast, there are numerous differences in the expression profiles of genes active in the dorsal ectoderm. Most notably, the subdivision of the extra-embryonic domain into separate amnion and serosa lineages in A. gambiae correlates with novel patterns of gene expression for several segmentation repressors. Moreover, the expanded amnion and serosa anlage correlates with a broader domain of Dpp signaling as compared with the D. melanogaster embryo. Evidence is presented that this expanded signaling is due to altered expression of the sog gene.

Key words: Mosquito, Anopheles gambiae, Embryo, Gastrulation, Amnion, Serosa, Gene network, Sog, Dpp, Zen, Dorsal-ventral patterning


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