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First published online June 25, 2007
doi: 10.1242/10.1242/dev.02864

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Common regulatory networks in leaf and fruit patterning revealed by mutations in the Arabidopsis ASYMMETRIC LEAVES1 gene

Hugo Alonso-Cantabrana^1,*, Juan José Ripoll^1,, Isabel Ochando^1,, Antonio Vera¹, Cristina Ferrándiz² and Antonio Martínez-Laborda^1,

¹ División de Genética, Universidad Miguel Hernández, Campus de San Juan, Ctra. de Valencia s/n, 03550-San Juan de Alicante, Spain.
² Instituto de Biología Molecular y Celular de Plantas (CSIC-UPV), Avda. de los Naranjos s/n, 46022-Valencia, Spain.

Author for correspondence (e-mail: laborda{at}umh.es)

Accepted 25 April 2007

Carpels and leaves are evolutionarily related organs, as the former are thought to be modified leaves. Therefore, developmental pathways that play crucial roles in patterning both organs are presumably conserved. In leaf primordia of Arabidopsis thaliana, the ASYMMETRIC LEAVES1 (AS1) gene interacts with AS2 to repress the class I KNOTTED1-like homeobox (KNOX) genes BREVIPEDICELLUS (BP), KNAT2 and KNAT6, restricting the expression of these genes to the meristem. In this report, we describe how AS1, presumably in collaboration with AS2, patterns the Arabidopsis gynoecium by repressing BP, which is expressed in the replum and valve margin, interacts in the replum with REPLUMLESS (RPL), an essential gene for replum development, and positively regulates the expression of this gene. Misexpression of BP in the gynoecium causes an increase in replum size, while the valve width is slightly reduced, and enhances the effect of mutations in FRUITFULL (FUL), a gene with an important function in valve development. Altogether, these findings strongly suggest that BP plays a crucial role in replum development. We propose a model for pattern formation along the mediolateral axis of the ovary, whereby three domains (replum, valve margin and valve) are specified by the opposing gradients of two antagonistic factors, valve factors and replum factors, the class I KNOX genes working as the latter.

Key words: Arabidopsis, Fruit development, Pattern formation, ASYMMETRIC LEAVES 1, BREVIPEDICELLUS (KNAT1), Class I KNOX genes