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First published online 4 July 2007
doi: 10.1242/dev.004184

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Notch signaling in vascular development and physiology

The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA.

e-mail: tom.gridley{at}jax.org

SUMMARY

Notch signaling is an ancient intercellular signaling mechanism that plays myriad roles during vascular development and physiology in vertebrates. These roles include regulation of artery/vein differentiation in endothelial and vascular smooth muscle cells, regulation of blood vessel sprouting and branching during both normal development and tumor angiogenesis, and the differentiation and physiological responses of vascular smooth muscle cells. Defects in Notch signaling also cause inherited vascular and cardiovascular diseases. In this review, I summarize recent findings and discuss the growing relevance of Notch pathway modulation for therapeutic applications in disease.

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