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First published online August 24, 2007
doi: 10.1242/10.1242/dev.004408
Review |
1 Max-Delbrueck-Center for Molecular Medicine, Robert-Roessle-Strasse 10,
D-13125 Berlin, Germany.
2 Max Planck Institute of Molecular Cell Biology and Genetics,
Pfotenhauerstrasse 108, D-01307 Dresden, Germany.
* e-mails: willnow{at}mdc-berlin.de; eaton{at}mpi-cbg.de
SUMMARY
Previously, the relevance of lipoproteins and their receptors has mainly been discussed in terms of cholesterol clearance in the adult organism. Now, findings from nematodes to fruit flies to mammals all point towards novel and unexpected roles for lipoprotein metabolism in the control of key regulatory pathways in the developing embryo, including signaling through steroid hormones and throughout the hedgehog and Wnt signaling pathways. Here, we discuss the emerging view of how lipoproteins and their receptors regulate embryogenesis.
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