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First published online August 24, 2007
doi: 10.1242/10.1242/dev.004408

Development 134, 3239-3249 (2007)
Published by The Company of Biologists 2007
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Review

Lipoproteins and their receptors in embryonic development: more than cholesterol clearance

Thomas E. Willnow1,*, Annette Hammes1 and Suzanne Eaton2,*

1 Max-Delbrueck-Center for Molecular Medicine, Robert-Roessle-Strasse 10, D-13125 Berlin, Germany.
2 Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, D-01307 Dresden, Germany.

* e-mails: willnow{at}mdc-berlin.de; eaton{at}mpi-cbg.de

SUMMARY

Previously, the relevance of lipoproteins and their receptors has mainly been discussed in terms of cholesterol clearance in the adult organism. Now, findings from nematodes to fruit flies to mammals all point towards novel and unexpected roles for lipoprotein metabolism in the control of key regulatory pathways in the developing embryo, including signaling through steroid hormones and throughout the hedgehog and Wnt signaling pathways. Here, we discuss the emerging view of how lipoproteins and their receptors regulate embryogenesis.




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© The Company of Biologists Ltd 2007