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First published online September 7, 2007
doi: 10.1242/10.1242/dev.008078

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Rab6 and the secretory pathway affect oocyte polarity in Drosophila

¹ Institut Jacques Monod, Unité Mixte de Recherche 7592, CNRS, Universités Paris 6 et Paris 7, 2 place Jussieu, F-75251, Paris Cedex 05, France.
² Cell Division Group, IRB, Parc Cientific de Barcelona, c/Josep Samitier 1-5, 08028 Barcelona, Spain.
³ Hybrigenics SA, 3-5 impasse Reille, 75014 Paris, France.
⁴ Unité Mixte de Recherche 144 CNRS/Institut Curie, Institut Curie, 26 rue d'Ulm, 75248, Paris Cedex 05, France.

^* Author for correspondence (e-mail: guichet{at}ijm.jussieu.fr)

Accepted 22 July 2007

SUMMARY

The Drosophila oocyte is a highly polarized cell. Secretion occurs towards restricted neighboring cells and asymmetric transport controls the localization of several mRNAs to distinct cortical compartments. Here, we describe a role for the Drosophila ortholog of the Rab6 GTPase, Drab6, in establishing cell polarity during oogenesis. We found that Drab6 localizes to Golgi and Golgi-derived membranes and interacts with BicD. We also provide evidence that Drab6 and BicD function together to ensure the correct delivery of secretory pathway components, such as the TGF homolog Gurken, to the plasma membrane. Moreover, in the absence of Drab6, osk mRNA localization and the organization of microtubule plus-ends at the posterior of the oocyte were both severely affected. Our results point to a possible connection between Rab protein-mediated secretion, organization of the cytoskeleton and mRNA transport.

Key words: Rab6, Secretory pathway, RNA transport, Gurken, Microtubules, Bicaudal D, oskar mRNA

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