spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

First published online 6 December 2006
doi: 10.1242/dev.02721

Development 134, 261-272 (2007)
Published by The Company of Biologists 2007
This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Supplementary Material
Right arrow All Versions of this Article:
dev.02721v1
134/2/261    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Related articles in Development
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kurek, D.
Right arrow Articles by Grosveld, F. G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kurek, D.
Right arrow Articles by Grosveld, F. G.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Transcriptome and phenotypic analysis reveals Gata3-dependent signalling pathways in murine hair follicles

Dorota Kurek1, George A. Garinis2, J. Hikke van Doorninck3, Jacqueline van der Wees1 and Frank G. Grosveld1,*

1 Department of Cell Biology, Erasmus Medical Center, P.O. Box 1738, 3000 DR Rotterdam, The Netherlands.
2 Department of Genetics, Erasmus Medical Center, P.O. Box 1738, 3000 DR Rotterdam, The Netherlands.
3 Department of Obstetrics and Gynecology, Erasmus Medical Center, P.O. Box 1738, 3000 DR Rotterdam, The Netherlands.

* Author for correspondence (e-mail: f.grosveld{at}erasmusmc.nl)

Accepted 31 October 2006

The transcription factor Gata3 is crucially involved in epidermis and hair follicle differentiation. Yet, little is known about how Gata3 co-ordinates stem cell lineage determination in skin, what pathways are involved and how Gata3 differentially regulates distinct cell populations within the hair follicle. Here, we describe a conditional Gata3-/- mouse (K14-Gata3-/-) in which Gata3 is specifically deleted in epidermis and hair follicles. K14-Gata3-/- mice show aberrant postnatal growth and development, delayed hair growth and maintenance, abnormal hair follicle organization and irregular pigmentation. After the first hair cycle, the germinative layer surrounding the dermal papilla was not restored; instead, proliferation was pronounced in basal epidermal cells. Transcriptome analysis of laser-dissected K14-Gata3-/- hair follicles revealed mitosis, epithelial differentiation and the Notch, Wnt and BMP signaling pathways to be significantly overrepresented. Elucidation of these pathways at the RNA and protein levels and physiologic endpoints suggests that Gata3 integrates diverse signaling networks to regulate the balance between hair follicle and epidermal cell fates.

Key words: Gata3, Hair follicle, Epidermis, Laser capture microscopy, Microarray, Mouse


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?

Related articles in Development:

A hair-raising choice for Gata3

Development 2007 134: e206. [Full Text]  



This article has been cited by other articles:


Home page
 DevelopmentHome page
J. Hwang, T. Mehrani, S. E. Millar, and M. I. Morasso
Dlx3 is a crucial regulator of hair follicle differentiation and cycling
Development, September 15, 2008; 135(18): 3149 - 3159.
[Abstract] [Full Text] [PDF]


© The Company of Biologists Ltd 2007