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First published online 19 September 2007
doi: 10.1242/dev.006585

Development 134, 3703-3712 (2007)
Published by The Company of Biologists 2007
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The pattern of ß-catenin responsiveness within the mammary gland is regulated by progesterone receptor

Minoti Hiremath1, John P. Lydon2 and Pamela Cowin1,3,*

1 Department of Cell Biology, NYU School of Medicine, MSB 618, 550 1st Avenue, New York, NY 10016, USA.
2 Department of Molecular and Cellular Biology, M533A, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.
3 Department of Dermatology, NYU School of Medicine, MSB 618, 550 1st Avenue, New York, NY 10016, USA.

* Author for correspondence (e-mail: cowinp01{at}med.nyu.edu)

Accepted 27 July 2007

Experiments involving ß-catenin loss- and gain-of-function in the mammary gland have decisively demonstrated the role of this protein in normal alveologenesis. However, the relationship between hormonal and ß-catenin signaling has not been investigated. In this study, we demonstrate that activated ß-catenin rescues alveologenesis in progesterone receptor (PR; Pgr)-null mice during pregnancy. Two distinct subsets of mammary cells respond to expression of {Delta}N89ß-catenin. Cells at ductal tips are inherently ß-catenin-responsive and form alveoli in the absence of PR. However, PR activity confers ß-catenin responsiveness to progenitor cells along the lateral ductal borders in the virgin gland. Once activated by ß-catenin, responding cells switch on an alveolar differentiation program that is indistinguishable from that observed in pregnancy and is curtailed by PR signaling.

Key words: Beta-catenin, Breast, Progesterone receptor, Mammary gland, Wnt, Mouse, Stem cells


Related articles in Development:

Progesterone and ß-catenin: priming mammary development

Development 2007 134: e2005. [Full Text]  



This article has been cited by other articles:


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C. J. Watson and W. T. Khaled
Mammary development in the embryo and adult: a journey of morphogenesis and commitment
Development, March 15, 2008; 135(6): 995 - 1003.
[Abstract] [Full Text] [PDF]


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