QUICK SEARCH:   [advanced] Author: Keyword(s):
Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents

First published online 3 October 2007
doi: 10.1242/dev.005447

This Article Figures Only Full Text Full Text (PDF) Supplementary Material All Versions of this Article: dev.005447v1 134/21/3883    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Hack, I. Articles by Frotscher, M. Search for Related Content PubMed PubMed Citation Articles by Hack, I. Articles by Frotscher, M. Social Bookmarking                         What's this?

Divergent roles of ApoER2 and Vldlr in the migration of cortical neurons

Iris Hack^1,*, Sabine Hellwig^1,2,*, Dirk Junghans³, Bianka Brunne⁴, Hans H. Bock⁴, Shanting Zhao¹ and Michael Frotscher^1,4,

¹ Institut für Anatomie und Zellbiologie, Albert-Ludwigs-Universität Freiburg, D-79104 Freiburg, Germany.
² Neurologische Universitätsklinik, Neurozentrum, Albert-Ludwigs-Universität Freiburg, D-79104 Freiburg, Germany.
³ Max-Planck-Institut für Immunbiologie, D-79108 Freiburg, Germany.
⁴ Zentrum für Neurowissenschaften, Albert-Ludwigs-Universität Freiburg, D-79104 Freiburg, Germany.

Author for correspondence (e-mail: Michael.Frotscher{at}anat.uni-freiburg.de)

Accepted 16 August 2007

Reelin, its lipoprotein receptors [very low density lipoprotein receptor (Vldlr) and apolipoprotein E receptor 2 (ApoER2; also known as Lrp8)], and the cytoplasmic adaptor protein disabled 1 (Dab1) are important for the correct formation of layers in the cerebral cortex. Reeler mice lacking the reelin protein show altered radial neuronal migration resulting in an inversion of cortical layers. ApoER2 Vldlr double-knockout mutants and Dab1 mutants show a reeler-like phenotype, whereas milder phenotypes are found if only one of the two lipoprotein receptors for reelin is absent. However, the precise role of the individual reelin receptors in neuronal migration remained unclear. In the study reported here, we performed fate mapping of newly generated cortical neurons in single and double receptor mutants using bromodeoxyuridine-labeling and layer-specific markers. We present evidence for divergent roles of the two reelin receptors Vldlr and ApoER2, with Vldlr mediating a stop signal for migrating neurons and ApoER2 being essential for the migration of late generated neocortical neurons.

Key words: Lipoprotein receptors, disabled 1, Reelin, Layer formation, Neuronal migration

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

Related articles in Development:

Divergent roles for reelin receptors revealed

Development 2007 134: e2104. [Full Text]  

This article has been cited by other articles:

				P. Chameau, D. Inta, T. Vitalis, H. Monyer, W. J. Wadman, and J. A. van Hooft The N-terminal region of reelin regulates postnatal dendritic maturation of cortical pyramidal neurons PNAS, April 28, 2009; 106(17): 7227 - 7232. [Abstract] [Full Text] [PDF]

				X. Chai, E. Forster, S. Zhao, H. H. Bock, and M. Frotscher Reelin Stabilizes the Actin Cytoskeleton of Neuronal Processes by Inducing n-Cofilin Phosphorylation at Serine3 J. Neurosci., January 7, 2009; 29(1): 288 - 299. [Abstract] [Full Text] [PDF]

				X. Fan, H.-J. Kim, D. Bouton, M. Warner, and J.-A. Gustafsson Expression of liver X receptor {beta} is essential for formation of superficial cortical layers and migration of later-born neurons PNAS, September 9, 2008; 105(36): 13445 - 13450. [Abstract] [Full Text] [PDF]