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First published online 10 October 2007
doi: 10.1242/dev.001131

Development 134, 3959-3965 (2007)
Published by The Company of Biologists 2007
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Review

Genome-wide analysis of DNA methylation patterns

Daniel Zilberman1 and Steven Henikoff2,3

1 University of California, 211 Koshland Hall, Berkeley, CA 94720, USA.
2 Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA.
3 Howard Hughes Medical Institute, 1100 Fairview Avenue North, Seattle, WA 98109, USA.

e-mail: steveh{at}fhcrc.org

SUMMARY

Cytosine methylation is the most common covalent modification of DNA in eukaryotes. DNA methylation has an important role in many aspects of biology, including development and disease. Methylation can be detected using bisulfite conversion, methylation-sensitive restriction enzymes, methyl-binding proteins and anti-methylcytosine antibodies. Combining these techniques with DNA microarrays and high-throughput sequencing has made the mapping of DNA methylation feasible on a genome-wide scale. Here we discuss recent developments and future directions for identifying and mapping methylation, in an effort to help colleagues to identify the approaches that best serve their research interests.




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