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First published online 17 October 2007
doi: 10.1242/dev.007823

Development 134, 4011-4021 (2007)
Published by The Company of Biologists 2007
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Reciprocal endoderm-mesoderm interactions mediated by fgf24 and fgf10 govern pancreas development

Isabelle Manfroid1,*, François Delporte1, Ariane Baudhuin1, Patrick Motte2, Carl J. Neumann3, Marianne L. Voz1, Joseph A. Martial1 and Bernard Peers1

1 GIGA-Research-Unité de Biologie Moléculaire et Génie Génétique, Tour B34, Université de Liège, B-4000 Sart Tilman, Belgium.
2 Laboratoire de Biologie Cellulaire Végétale, Cellule d'Appui Technologique en Microscopie, Université de Liège, Institut de Botanique, Bâtiment B22, B-4000 Sart-Tilman, Belgium.
3 European Molecular Biology Laboratory (EMBL), Meyerhofstrasse 1, D-69117 Heidelberg, Germany.

* Author for correspondence (e-mail: isabelle.manfroid{at}ulg.ac.be)

Accepted 22 August 2007

In amniotes, the pancreatic mesenchyme plays a crucial role in pancreatic epithelium growth, notably through the secretion of fibroblast growth factors. However, the factors involved in the formation of the pancreatic mesenchyme are still largely unknown. In this study, we characterize, in zebrafish embryos, the pancreatic lateral plate mesoderm, which is located adjacent to the ventral pancreatic bud and is essential for its specification and growth. We firstly show that the endoderm, by expressing the fgf24 gene at early stages, triggers the patterning of the pancreatic lateral plate mesoderm. Based on the expression of isl1, fgf10 and meis genes, this tissue is analogous to the murine pancreatic mesenchyme. Secondly, Fgf10 acts redundantly with Fgf24 in the pancreatic lateral plate mesoderm and they are both required to specify the ventral pancreas. Our results unveil sequential signaling between the endoderm and mesoderm that is critical for the specification and growth of the ventral pancreas, and explain why the zebrafish ventral pancreatic bud generates the whole exocrine tissue.

Key words: Zebrafish, Pancreas, FGF, Signaling, Endoderm, Mesoderm, ptf1a


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Development 2007 134: e2202. [Full Text]  





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