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First published online 31 October 2007
doi: 10.1242/dev.010397

Development 134, 4273-4282 (2007)
Published by The Company of Biologists 2007
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A wave of EGFR signaling determines cell alignment and intercalation in the Drosophila tracheal placode

Mayuko Nishimura1,2, Yoshiko Inoue1,* and Shigeo Hayashi1,2,{dagger}

1 Riken Center for Developmental Biology, 2-2-3 Minatojima-minamimachi, Chuo-ku Kobe 650-0047, Japan.
2 Department of biology, Kobe University Graduate School of Science, Kobe, Japan.

{dagger} Author for correspondence (e-mail: shayashi{at}cdb.riken.jp)

Accepted 7 September 2007

Invagination of organ placodes converts flat epithelia into three-dimensional organs. Cell tracing in the Drosophila tracheal placode revealed that, in the 30-minute period before invagination, cells enter mitotic quiescence and form short rows that encircle the future invagination site. The cells in the rows align to form a smooth boundary (`boundary smoothing'), accompanied by a transient increase in myosin at the boundary and cell intercalation oriented in parallel with the cellular rows. Cells then undergo apical constriction and invaginate, followed by radially oriented mitosis in the placode. Prior to invagination, ERK MAP kinase is activated in an outward circular wave, with the wave front often correlating with the smoothing cell boundaries. EGFR signaling is required for myosin accumulation and cell boundary smoothing, suggesting its propagation polarizes the planar cell rearrangement in the tracheal placode, and coordinates the timing and position of intrinsic cell internalization activities.

Key words: Drosophila melanogaster, EGFR, Cell intercalation, Invagination, Myosin, Trachea




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M. Affolter and E. Caussinus
Tracheal branching morphogenesis in Drosophila: new insights into cell behaviour and organ architecture
Development, June 15, 2008; 135(12): 2055 - 2064.
[Abstract] [Full Text] [PDF]


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