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First published online 21 December 2006
doi: 10.1242/dev.02762

Development 134, 439-448 (2007)
Published by The Company of Biologists 2007
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Review

Getting axons onto the right path: the role of transcription factors in axon guidance

Samantha J. Butler1 and Guy Tear2,*

1 Department of Biological Sciences, HNB 201, 3641 Watt Way, University of Southern California, Los Angeles, CA 90089, USA.
2 MRC Centre for Developmental Neurobiology, New Hunts House, Guys Campus, Kings College, London SE1 1UL, UK.

* Author for correspondence (e-mail: guy.tear{at}kcl.ac.uk)

SUMMARY

The normal function of the nervous system requires that the constituent neurons are precisely `wired together'. During embryogenesis, each neuron extends an axonal process, which can navigate a considerable distance to its target. Although a number of the receptors and guidance signals that direct axonal growth have been identified, less is known about the transcription factors that regulate the expression of these molecules within the neuron and its environment. This review examines recent studies in vertebrates and Drosophila that address the identity of the transcription factors that either control the repertoire of guidance receptors and signals that permits an axon to take a particular trajectory or act themselves as novel extracellular guidance factors.


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