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First published online January 26, 2007
doi: 10.1242/10.1242/dev.02772

Development 134, 647-658 (2007)
Published by The Company of Biologists 2007
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Review

Tissue/planar cell polarity in vertebrates: new insights and new questions

Yanshu Wang1 and Jeremy Nathans1,2

1 Department of Molecular Biology and Genetics, Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
2 Departments of Neuroscience and Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

e-mails: ywang{at}mail.jhmi.edu; jnathans{at}jhmi.edu

SUMMARY

This review focuses on the tissue/planar cell polarity (PCP) pathway and its role in generating spatial patterns in vertebrates. Current evidence suggests that PCP integrates both global and local signals to orient diverse structures with respect to the body axes. Interestingly, the system acts on both subcellular structures, such as hair bundles in auditory and vestibular sensory neurons, and multicellular structures, such as hair follicles. Recent work has shown that intriguing connections exist between the PCP-based orienting system and left-right asymmetry, as well as between the oriented cell movements required for neural tube closure and tubulogenesis. Studies in mice, frogs and zebrafish have revealed that similarities, as well as differences, exist between PCP in Drosophila and vertebrates.


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