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First published online 21 February 2007
doi: 10.1242/dev.000067

Development 134, 1253-1257 (2007)
Published by The Company of Biologists 2007
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Research Report

Dynamic somite cell rearrangements lead to distinct waves of myotome growth

Frank Stellabotte, Betsy Dobbs-McAuliffe, Daniel A. Fernández*, Xuesong Feng{dagger} and Stephen H. Devoto{ddagger}

Department of Biology, Wesleyan University, Middletown, CT 06459, USA.

{ddagger} Author for correspondence (e-mail: sdevoto{at}wesleyan.edu)

Accepted 1 February 2007

SUMMARY

The myogenic precursors responsible for muscle growth in amniotes develop from the dermomyotome, an epithelium at the external surface of the somite. In teleosts, the myogenic precursors responsible for growth have not been identified. We have used single cell lineage labeling in zebrafish to show that anterior border cells of epithelial somites are myogenic precursors responsible for zebrafish myotome growth. These cells move to the external surface of the embryonic myotome and express the transcription factor Pax7. Some remain on the external surface and some incorporate into the fast myotome, apparently by moving between differentiated slow fibres. The posterior cells of the somite, by contrast, elongate into medial muscle fibres. The surprising movement of the anterior somite cells to the external somite surface transforms a segmentally repeated arrangement of myogenic precursors into a medio-lateral arrangement similar to that seen in amniotes.

Key words: Myotome, Anterior border cells, Cell fate, Paraxial mesoderm, Somite, Dermomyotome, Zebrafish, Fast muscle, Pax7, Myogenesis, Teleost


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