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First published online 28 February 2007
doi: 10.1242/dev.02823

Development 134, 1337-1346 (2007)
Published by The Company of Biologists 2007
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Antagonistic and cooperative actions of the EGFR and Dpp pathways on the iroquois genes regulate Drosophila mesothorax specification and patterning

Annalisa Letizia*, Rosa Barrio{dagger} and Sonsoles Campuzano{ddagger}

Centro de Biología Molecular Severo Ochoa, CSIC and UAM, Cantoblanco, 28049 Madrid, Spain.

{ddagger} Author for correspondence (e-mail: scampuzano{at}cbm.uam.es)

Accepted 31 January 2007

In Drosophila, restricted expression of the Iroquois complex (Iro-C) genes in the proximal region of the wing imaginal disc contributes to its territorial subdivision, specifying first the development of the notum versus the wing hinge, and subsequently, that of the lateral versus medial notum. Iro-C expression is under the control of the EGFR and Dpp signalling pathways. To analyze how both pathways cooperate in the regulation of Iro-C, we isolated several wing disc-specific cis-regulatory elements of the complex. One of these (IroRE2) integrates competing inputs of the EGFR and Dpp pathways, mediated by the transcription factors Pointed (downstream of EGFR pathway) and Pannier/U-shaped and Mothers against Dpp (Mad), in the case of Dpp. By contrast, a second element (IroRE1) mediates activation by both the EGFR and Dpp pathways, thus promoting expression of Iro-C in a region of elevated levels of Dpp signalling, the prospective lateral notum near the anterior-posterior compartment boundary. These results help define the molecular mechanisms of the interplay between the EGFR and Dpp pathways in the specification and patterning of the notum.

Key words: Iroquois complex, Imaginal wing disc, Drosophila, Notum development, Dpp signalling, EGFR signalling




This article has been cited by other articles:


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J. de Navascues and J. Modolell
tailup, a LIM-HD gene, and Iro-C cooperate in Drosophila dorsal mesothorax specification
Development, May 1, 2007; 134(9): 1779 - 1788.
[Abstract] [Full Text] [PDF]


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