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First published online 28 February 2007
doi: 10.1242/dev.02828

Development 134, 1431-1441 (2007)
Published by The Company of Biologists 2007
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Shroom family proteins regulate {gamma}-tubulin distribution and microtubule architecture during epithelial cell shape change

Chanjae Lee, Heather M. Scherr and John B. Wallingford*

Department of Molecular Cell and Developmental Biology, and Institute for Cellular and Molecular Biology, University of Texas, Austin, TX 78712, USA.

* Author for correspondence (e-mail: wallingford{at}mail.utexas.edu)

Accepted 19 January 2007

Cell shape changes require the coordination of actin and microtubule cytoskeletons. The molecular mechanisms by which such coordination is achieved remain obscure, particularly in the context of epithelial cells within developing vertebrate embryos. We have identified a novel role for the actin-binding protein Shroom3 as a regulator of the microtubule cytoskeleton during epithelial morphogenesis. We show that Shroom3 is sufficient and also necessary to induce a redistribution of the microtubule regulator {gamma}-tubulin. Moreover, this change in {gamma}-tubulin distribution underlies the assembly of aligned arrays of microtubules that drive apicobasal cell elongation. Finally, experiments with the related protein, Shroom1, demonstrate that {gamma}-tubulin regulation is a conserved feature of this protein family. Together, the data demonstrate that Shroom family proteins govern epithelial cell behaviors by coordinating the assembly of both microtubule and actin cytoskeletons.

Key words: Shroom, gamma-tubulin, microtubule, neural tube defect, morphogenesis, Xenopus


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