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First published online 7 March 2007
doi: 10.1242/dev.000117

Development 134, 1455-1463 (2007)
Published by The Company of Biologists 2007
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Review

Foxe view of lens development and disease

Olga Medina-Martinez and Milan Jamrich*

Department of Molecular and Cellular Biology, and Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.

* Author for correspondence (e-mail: jamrich{at}bcm.tmc.edu)

SUMMARY

The recent identification of a mutation in Foxe3 that causes congenital primary aphakia in humans marks an important milestone. Congenital primary aphakia is a rare developmental disease in which the lens does not form. Previously, Foxe3 had been shown to play a crucial role in vertebrate lens formation and this gene is one of the earliest integrators of several signaling pathways that cooperate to form a lens. In this review, we highlight recent advances that have led to a better understanding of the developmental processes and gene regulatory networks involved in lens development and disease.




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