QUICK SEARCH:   [advanced] Author: Keyword(s):
Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents

First published online 14 March 2007
doi: 10.1242/dev.02829

This Article Figures Only Full Text Full Text (PDF) Supplementary Material All Versions of this Article: dev.02829v1 134/8/1499    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Andoniadou, C. L. Articles by Martinez-Barbera, J. P. Search for Related Content PubMed PubMed Citation Articles by Andoniadou, C. L. Articles by Martinez-Barbera, J. P. Pubmed/NCBI databases Gene GEO Profiles HomoloGene Protein UniGene Substance via MeSH Social Bookmarking                         What's this?

Lack of the murine homeobox gene Hesx1 leads to a posterior transformation of the anterior forebrain

¹ Neural Development Unit, UCL-Institute of Child Health, 30 Guilford Street, WC1N 1EH, London, UK
² Biochemistry, Endocrinology and Metabolism Unit, UCL-Institute of Child Health, 30 Guilford Street, WC1N 1EH, London, UK.
³ National Institute for Medical Research, The Ridgeway, Mill Hill, NW7 1AA, London, UK.

^* Author for correspondence (e-mail: j.martinez-barbera{at}ich.ucl.ac.uk)

Accepted 5 February 2007

The homeobox gene Hesx1 is an essential repressor that is required within the anterior neural plate for normal forebrain development in mouse and humans. Combining genetic cell labelling and marker analyses, we demonstrate that the absence of Hesx1 leads to a posterior transformation of the anterior forebrain (AFB) during mouse development. Our data suggest that the mechanism underlying this transformation is the ectopic activation of Wnt/ß-catenin signalling within the Hesx1 expression domain in the AFB. When ectopically expressed in the developing mouse embryo, Hesx1 alone cannot alter the normal fate of posterior neural tissue. However, conditional expression of Hesx1 within the AFB can rescue the forebrain defects observed in the Hesx1 mutants. The results presented here provide new insights into the function of Hesx1 in forebrain formation.

Key words: Hesx1, Anterior forebrain, Wnt, ß-catenin, Cre, Rosa26

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				K. S Alatzoglou, D. Kelberman, and M. T Dattani The role of SOX proteins in normal pituitary development J. Endocrinol., March 1, 2009; 200(3): 245 - 258. [Abstract] [Full Text] [PDF]

				E. Sajedi, C. Gaston-Massuet, M. Signore, C. L. Andoniadou, D. Kelberman, S. Castro, H. C. Etchevers, D. Gerrelli, M. T. Dattani, and J. P. Martinez-Barbera Analysis of mouse models carrying the I26T and R160C substitutions in the transcriptional repressor HESX1 as models for septo-optic dysplasia and hypopituitarism Dis. Model. Mech., November 1, 2008; 1(4-5): 241 - 254. [Abstract] [Full Text] [PDF]

				S. L. Lewis, P.-L. Khoo, R. A. De Young, K. Steiner, C. Wilcock, M. Mukhopadhyay, H. Westphal, R. V. Jamieson, L. Robb, and P. P. L. Tam Dkk1 and Wnt3 interact to control head morphogenesis in the mouse Development, May 15, 2008; 135(10): 1791 - 1801. [Abstract] [Full Text] [PDF]

				D. Kelberman, S. C. P. de Castro, S. Huang, J. A. Crolla, R. Palmer, J. W. Gregory, D. Taylor, L. Cavallo, M. F. Faienza, R. Fischetto, et al. SOX2 Plays a Critical Role in the Pituitary, Forebrain, and Eye during Human Embryonic Development J. Clin. Endocrinol. Metab., May 1, 2008; 93(5): 1865 - 1873. [Abstract] [Full Text] [PDF]