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First published online 14 March 2007
doi: 10.1242/dev.02829

Development 134, 1499-1508 (2007)
Published by The Company of Biologists 2007
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Lack of the murine homeobox gene Hesx1 leads to a posterior transformation of the anterior forebrain

Cynthia L. Andoniadou1, Massimo Signore1, Ezat Sajedi1, Carles Gaston-Massuet1, Daniel Kelberman2, Alan J. Burns1, Nobue Itasaki3, Mehul Dattani2 and Juan Pedro Martinez-Barbera1,*

1 Neural Development Unit, UCL-Institute of Child Health, 30 Guilford Street, WC1N 1EH, London, UK
2 Biochemistry, Endocrinology and Metabolism Unit, UCL-Institute of Child Health, 30 Guilford Street, WC1N 1EH, London, UK.
3 National Institute for Medical Research, The Ridgeway, Mill Hill, NW7 1AA, London, UK.

* Author for correspondence (e-mail: j.martinez-barbera{at}ich.ucl.ac.uk)

Accepted 5 February 2007

The homeobox gene Hesx1 is an essential repressor that is required within the anterior neural plate for normal forebrain development in mouse and humans. Combining genetic cell labelling and marker analyses, we demonstrate that the absence of Hesx1 leads to a posterior transformation of the anterior forebrain (AFB) during mouse development. Our data suggest that the mechanism underlying this transformation is the ectopic activation of Wnt/ß-catenin signalling within the Hesx1 expression domain in the AFB. When ectopically expressed in the developing mouse embryo, Hesx1 alone cannot alter the normal fate of posterior neural tissue. However, conditional expression of Hesx1 within the AFB can rescue the forebrain defects observed in the Hesx1 mutants. The results presented here provide new insights into the function of Hesx1 in forebrain formation.

Key words: Hesx1, Anterior forebrain, Wnt, ß-catenin, Cre, Rosa26




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