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First published online 4 April 2007
doi: 10.1242/dev.02844

Development 134, 1779-1788 (2007)
Published by The Company of Biologists 2007
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tailup, a LIM-HD gene, and Iro-C cooperate in Drosophila dorsal mesothorax specification

Joaquín de Navascués and Juan Modolell*

Centro de Biología Molecular Severo Ochoa, CSIC and UAM, Cantoblanco, 28049 Madrid, Spain.

* Author for correspondence (e-mail: jmodol{at}cbm.uam.es)

Accepted 26 February 2007

The LIM-HD gene tailup (tup; also known as islet) has been categorised as a prepattern gene that antagonises the formation of sensory bristles on the notum of Drosophila by downregulating the expression of the proneural achaete-scute genes. Here we show that tup has an earlier function in the development of the imaginal wing disc; namely, the specification of the notum territory. Absence of tup function causes cells of this anlage to upregulate different wing-hinge genes and to lose expression of some notum genes. Consistently, these cells differentiate hinge structures or modified notum cuticle. The LIM-HD co-factors Chip and Ssdp are also necessary for notum specification. This suggests that Tup acts in this process in a complex with Chip and Ssdp. Overexpression of tup, together with araucan, a `pronotum' gene of the iroquois complex (Iro-C), synergistically reinforces the weak capacity of either gene, when overexpressed singly, to induce ectopic notum-like development. Whereas the Iro-C genes are activated in the notum anlage by EGFR signalling, tup is positively regulated by Dpp signalling. Our data support a model in which the EGFR and Dpp signalling pathways, with their respective downstream Iro-C and tup genes, converge and cooperate to commit cells to the notum developmental fate.

Key words: tailup, islet, Notum development, EGFR, Dpp, Drosophila


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© The Company of Biologists Ltd 2007