QUICK SEARCH:   [advanced] Author: Keyword(s):
Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents

First published online 21 May 2008
doi: 10.1242/dev.015453

This Article Figures Only Full Text Full Text (PDF) All Versions of this Article: dev.015453v1 135/13/2207    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by de Rooij, D. G. Articles by Mizrak, S. C. Search for Related Content PubMed PubMed Citation Articles by de Rooij, D. G. Articles by Mizrak, S. C. Social Bookmarking                         What's this?

Deriving multipotent stem cells from mouse spermatogonial stem cells: a new tool for developmental and clinical research

¹ Center for Reproductive Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands.
² Department of Endocrinology and Metabolism, Faculty of Science, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands.

^* Author for correspondence (e-mail: d.g.derooij{at}uu.nl)

SUMMARY

In recent years, embryonic stem (ES) cell-like cells have been obtained from cultured mouse spermatogonial stem cells (SSCs). These advances have shown that SSCs can transition from being the stem cell-producing cells of spermatogenesis to being multipotent cells that can differentiate into derivatives of all three germ layers. As such, they offer new possibilities for studying the mechanisms that regulate stem cell differentiation. The extension of these findings to human SSCs offers a route to obtaining personalized ES-like or differentiated cells for use in regenerative medicine. Here, we compare the different approaches used to derive ES-like cells from SSCs and discuss their importance to clinical and developmental research.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				S.C. Mizrak, J.V. Chikhovskaya, H. Sadri-Ardekani, S. van Daalen, C.M. Korver, S.E. Hovingh, H.L. Roepers-Gajadien, A. Raya, K. Fluiter, Th.M. de Reijke, et al. Embryonic stem cell-like cells derived from adult human testis Hum. Reprod., October 8, 2009; (2009) dep354v1. [Abstract] [Full Text] [PDF]

				S. Takashima, M. Takehashi, J. Lee, S. Chuma, M. Okano, K. Hata, I. Suetake, N. Nakatsuji, H. Miyoshi, S. Tajima, et al. Abnormal DNA Methyltransferase Expression in Mouse Germline Stem Cells Results in Spermatogenic Defects Biol Reprod, July 1, 2009; 81(1): 155 - 164. [Abstract] [Full Text] [PDF]

				A. Gromley, M. L. Churchman, F. Zindy, and C. J. Sherr Transient expression of the Arf tumor suppressor during male germ cell and eye development in Arf-Cre reporter mice PNAS, April 14, 2009; 106(15): 6285 - 6290. [Abstract] [Full Text] [PDF]

				J. Lee, M. Kanatsu-Shinohara, N. Ogonuki, H. Miki, K. Inoue, T. Morimoto, H. Morimoto, A. Ogura, and T. Shinohara Heritable Imprinting Defect Caused by Epigenetic Abnormalities in Mouse Spermatogonial Stem Cells Biol Reprod, March 1, 2009; 80(3): 518 - 527. [Abstract] [Full Text] [PDF]