spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

First published online 28 May 2008
doi: 10.1242/dev.019547

Development 135, 2263-2275 (2008)
Published by The Company of Biologists 2008
This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Supplementary Material
Right arrow All Versions of this Article:
dev.019547v1
135/13/2263    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Yoshimura, S.
Right arrow Articles by Shaham, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Yoshimura, S.
Right arrow Articles by Shaham, S.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

mls-2 and vab-3 control glia development, hlh-17/Olig expression and glia-dependent neurite extension in C. elegans

Satoshi Yoshimura1, John I. Murray2, Yun Lu1, Robert H. Waterston2,3 and Shai Shaham1,*

1 The Rockefeller University, Laboratory of Developmental Genetics, 1230 York Avenue, New York, NY 10065, USA.
2 Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA.
3 Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98105, USA.

* Author for correspondence (e-mail: shaham{at}rockefeller.edu)

Accepted 12 May 2008

Glia are essential components of nervous systems. However, genetic programs promoting glia development and regulating glia-neuron interactions have not been extensively explored. Here we describe transcriptional programs required for development and function of the C. elegans cephalic sheath (CEPsh) glia. We demonstrate ventral- and dorsal-restricted roles for the mls-2/Nkx/Hmx and vab-3/Pax6/Pax7 genes, respectively, in CEPsh glia differentiation and expression of the genes hlh-17/Olig and ptr-10/Patched-related. Using mls-2 and vab-3 mutants, as well as CEPsh glia-ablated animals, we show that CEPsh glia are important for sensory dendrite extension, axon guidance/branching within the nerve ring, and nerve ring assembly. We demonstrate that UNC-6/Netrin, expressed in ventral CEPsh glia, mediates glia-dependent axon guidance. Our results suggest possible similarities between CEPsh glia development and oligodendrocyte development in vertebrates, and demonstrate that C. elegans provides a unique environment for studying glial functions in vivo.

Key words: C. elegans, Glia, hlh-17, mls-2, Oligodendrocytes, vab-3


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 DevelopmentHome page
J. R. Kennerdell, R. D. Fetter, and C. I. Bargmann
Wnt-Ror signaling to SIA and SIB neurons directs anterior axon guidance and nerve ring placement in C. elegans
Development, November 15, 2009; 136(22): 3801 - 3810.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
T. Bacaj, M. Tevlin, Y. Lu, and S. Shaham
Glia Are Essential for Sensory Organ Function in C. elegans
Science, October 31, 2008; 322(5902): 744 - 747.
[Abstract] [Full Text] [PDF]


© The Company of Biologists Ltd 2008