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First published online June 20, 2008
doi: 10.1242/10.1242/dev.021279

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The discovery of a source of adult hematopoietic cells in the embryo

¹ Erasmus MC, Erasmus Stem Cell Institute, Department of Cell Biology, PO Box 2040, 3000 CA Rotterdam, The Netherlands.
² University of Edinburgh, MRC Centre for Regenerative Medicine/Institute for Stem Cell Research, Kings Buildings, West Mains Road, Edinburgh EH9 3JQ, UK.

e-mails: e.dzierzak{at}erasmusmc.nl; a.medvinsky{at}ed.ac.uk

SUMMARY

This essay is about the 1975 JEEM paper by Françoise Dieterlen-Lièvre (Dieterlen-Lièvre, 1975) and the studies that followed it, which indicated that the adult hematopoietic system in the avian embryo originates, not from the blood islands of the extraembryonic yolk sac as was then believed, but from the body of the embryo itself. Dieterlen-Lièvre's 1975 paper created a paradigm shift in hematopoietic research, and provided a new and lasting focus on hematopoietic activity within the embryo body.

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