spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

First published online June 20, 2008
doi: 10.1242/10.1242/dev.016105

Development 135, 2347-2360 (2008)
Published by The Company of Biologists 2008
This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Meléndez, A.
Right arrow Articles by Neufeld, T. P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Meléndez, A.
Right arrow Articles by Neufeld, T. P.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Review

The cell biology of autophagy in metazoans: a developing story

Alicia Meléndez1 and Thomas P. Neufeld2

1 Department of Biology, Queens College, 65-30 Kissena Boulevard, Flushing, NY 11367, USA.
2 Department of Genetics, Cell Biology and Development, University of Minnesota, 6-160 Jackson Hall, 321 Church Street SE, Minneapolis, MN 55455, USA.

e-mails: alicia.melendez{at}qc.cuny.edu; neufe003{at}umn.edu

SUMMARY

The cell biological phenomenon of autophagy (or `self-eating') has attracted increasing attention in recent years. In this review, we first address the cell biological functions of autophagy, and then discuss recent insights into the role of autophagy in animal development, particularly in C. elegans, Drosophila and mouse. Work in these and other model systems has also provided evidence for the involvement of autophagy in disease processes, such as neurodegeneration, tumorigenesis, pathogenic infection and aging. Insights gained from investigating the functions of autophagy in normal development should increase our understanding of its roles in human disease and its potential as a target for therapeutic intervention.


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 Mol. Cell. Biol.Home page
E. Y. W. Chan, A. Longatti, N. C. McKnight, and S. A. Tooze
Kinase-Inactivated ULK Proteins Inhibit Autophagy via Their Conserved C-Terminal Domains Using an Atg13-Independent Mechanism
Mol. Cell. Biol., January 1, 2009; 29(1): 157 - 171.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
A. Melendez and T. P. Neufeld
The cell biology of autophagy in metazoans: a developing story
J. Cell Sci., July 15, 2008; 121(14): e1406 - e1406.
[Full Text]


© The Company of Biologists Ltd 2008