spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

First published online July 11, 2008
doi: 10.1242/10.1242/dev.009324

Development 135, 2489-2503 (2008)
Published by The Company of Biologists 2008
This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Google Scholar
Right arrow Articles by Dessaud, E.
Right arrow Articles by Briscoe, J.
PubMed
Right arrow PubMed Citation
Right arrow Articles by Dessaud, E.
Right arrow Articles by Briscoe, J.

Review

Pattern formation in the vertebrate neural tube: a sonic hedgehog morphogen-regulated transcriptional network

Eric Dessaud1, Andrew P. McMahon2,* and James Briscoe1,*

1 Developmental Neurobiology, National Institute for Medical Research, The Ridgeway, Mill Hill, London, NW7 1AA, UK.
2 Department of Molecular and Cellular Biology, Harvard University, 16, Divinity Ave., Cambridge, MA 02138, USA.

* Authors for correspondence (e-mails: amcmahon{at}mcb.harvard.edu; james.briscoe{at}nimr.mrc.ac.uk)

SUMMARY

Neuronal subtype specification in the vertebrate neural tube is one of the best-studied examples of embryonic pattern formation. Distinct neuronal subtypes are generated in a precise spatial order from progenitor cells according to their location along the anterior-posterior and dorsal-ventral axes. Underpinning this organization is a complex network of multiple extrinsic and intrinsic factors. This review focuses on the molecular mechanisms and general strategies at play in ventral regions of the forming spinal cord, where sonic hedgehog-based morphogen signaling is a key determinant. We discuss recent advances in our understanding of these events and highlight unresolved questions.




This article has been cited by other articles:


Home page
 DevelopmentHome page
J. Jaeger, D. Irons, and N. Monk
Regulative feedback in pattern formation: towards a general relativistic theory of positional information
Development, October 1, 2008; 135(19): 3175 - 3183.
[Abstract] [Full Text] [PDF]


© The Company of Biologists Ltd 2008