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First published online August 12, 2008
doi: 10.1242/10.1242/dev.020974

Development 135, 2827-2838 (2008)
Published by The Company of Biologists 2008
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Review

The Fat and Warts signaling pathways: new insights into their regulation, mechanism and conservation

B. V. V. G. Reddy and Kenneth D. Irvine*

Howard Hughes Medical Institute, Waksman Institute and Department of Molecular Biology and Biochemistry, Rutgers The State University of New Jersey, Piscataway, NJ 08854, USA.

* Author for correspondence (e-mail irvine{at}waksman.rutgers.edu)

SUMMARY

A cassette of cytoplasmic Drosophila tumor suppressors, including the kinases Hippo and Warts, has recently been linked to the transmembrane tumor suppressor Fat. These proteins act within interconnected signaling pathways, the principal functions of which are to control the growth and polarity of developing tissues. Recent studies have enhanced our understanding of the basis for signal transduction by Fat and Warts pathways, including the identification of a DNA-binding protein at the end of the pathway, have established the conservation of Fat and Warts signaling from flies to mammals, and have given us new insights into their regulation and biological functions.


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