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First published online 13 August 2008
doi: 10.1242/dev.025205

Development 135, 3103-3111 (2008)
Published by The Company of Biologists 2008
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Planar polarity genes in the Drosophila wing regulate the localisation of the FH3-domain protein Multiple Wing Hairs to control the site of hair production

David Strutt* and Samantha J. Warrington

MRC Centre for Developmental and Biomedical Genetics and Department of Biomedical Science, University of Sheffield, Western Bank, Sheffield S10 2TN, UK.

* Author for correspondence (e-mail: d.strutt{at}sheffield.ac.uk)

Accepted 29 July 2008

The core planar polarity proteins play important roles in coordinating cell polarity, in part by adopting asymmetric subcellular localisations that are likely to serve as cues for cell polarisation by as yet uncharacterised pathways. Here we describe the role of Multiple Wing Hairs (Mwh), a novel formin homology 3 (FH3)-domain protein, which acts downstream of the core polarity proteins to restrict the production of actin-rich prehairs to distal cell edges in the Drosophila pupal wing. Mwh appears to function as a repressor of actin filament formation and, in its absence, ectopic actin bundles are seen across the entire apical surface of cells. We show that the proximally localised core polarity protein Strabismus acts via the downstream effector proteins Inturned, Fuzzy and Fritz to stabilise Mwh in apico-proximal cellular regions. In addition, the distally localised core polarity protein Frizzled positively promotes prehair initiation, suggesting that both proximal and distal cellular cues act together to ensure accurate prehair placement.

Key words: Planar polarity, Multiple Wing Hairs, Drosophila, Cell polarity, Frizzled, Actin


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Home page
 J. Cell Sci.Home page
D. Strutt and S. J. Warrington
Planar polarity genes in the Drosophila wing regulate the localisation of the FH3-domain protein Multiple Wing Hairs to control the site of hair production
J. Cell Sci., September 15, 2008; 121(18): e1807 - e1807.
[Full Text]


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