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First published online 20 August 2008
doi: 10.1242/dev.026443

Development 135, 3185-3190 (2008)
Published by The Company of Biologists 2008
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Research Report

GATA transcription factors integrate Wnt signalling during heart development

Boni A. Afouda1, Jennifer Martin1, Fei Liu1,*, Aldo Ciau-Uitz2, Roger Patient2 and Stefan Hoppler1,{dagger}

1 Institute of Medical Sciences, Cell and Developmental Biology Research Programme, School of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, UK.
2 MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford OX3 9DS, UK.

{dagger} Author for correspondence (e-mail: s.p.hoppler{at}abdn.ac.uk)

Accepted 29 July 2008

SUMMARY

Cardiogenesis is inhibited by canonical Wnt/β-catenin signalling and stimulated by non-canonical Wnt11/JNK signalling, but how these two signalling pathways crosstalk is currently unknown. Here, we show that Wnt/β-catenin signalling restricts cardiogenesis via inhibition of GATA gene expression, as experimentally reinstating GATA function overrides β-catenin-mediated inhibition and restores cardiogenesis. Furthermore, we show that GATA transcription factors in turn directly regulate Wnt11 gene expression, and that Wnt11 is required to a significant degree for mediating the cardiogenesis-promoting function of GATA transcription factors. These results demonstrate that GATA factors occupy a central position between canonical and non-canonical Wnt signalling in regulating heart muscle formation.

Key words: Cardiomyogenesis, GATA, Heart, Wnt, Xenopus




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B. A. Afouda, J. Martin, F. Liu, A. Ciau-Uitz, R. Patient, and S. Hoppler
GATA transcription factors integrate Wnt signalling during heart development
J. Cell Sci., October 1, 2008; 121(19): e1906 - e1906.
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