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First published online December 21, 2007
doi: 10.1242/10.1242/dev.001883
Review |
1 Massachusetts General Hospital - Cardiovascular Research Center, Charles River
Plaza/CPZN 3208, 185 Cambridge Street, Boston, MA 02114, USA.
2 Klinikum rechts der Isar und Deutsches Herzzentrum - Technische
Universität München, I. Medizinische Klinik - Molekulare
Kardiologie, Ismaninger Strasse 22, 81675 München, Germany.
3 Department of Stem Cell and Regenerative Biology, Harvard University and the
Harvard Stem Cell Institute, Cambridge, MA 02138, USA.
* Authors for correspondence (e-mails: klaugwitz{at}med1.med.tum.de, amoretti{at}med1.med.tum.de, kchien{at}partners.org)
SUMMARY
The creation of regenerative stem cell therapies for heart disease requires that we understand the molecular mechanisms that govern the fates and differentiation of the diverse muscle and non-muscle cell lineages of the heart. Recently, different cardiac cell types have been reported to arise from a common, multipotent Islet1 (Isl1)-positive progenitor, suggesting that a clonal model of heart lineage diversification might occur that is analogous to hematopoiesis. The ability to isolate, renew and differentiate Isl1+ precursors from postnatal and embryonic hearts and from embryonic stem cells provides a powerful cell-based system for characterizing the signaling pathways that control cardiovascular progenitor formation, renewal, lineage specification and conversion to specific differentiated progeny.
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