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First published online 11 September 2008
doi: 10.1242/dev.027078

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Temporal progression of hypothalamic patterning by a dual action of BMP

MRC Centre for Developmental and Biomedical Genetics and Department of Biomedical Science, University of Sheffield, Sheffield S10 2TN, UK.

^* Author for correspondence (e-mail: m.placzek{at}sheffield.ac.uk)

Accepted 12 August 2008

SUMMARY

In the developing chick hypothalamus, Shh and BMPs are expressed in a spatially overlapping, but temporally consecutive, manner. Here, we demonstrate how the temporal integration of Shh and BMP signalling leads to the late acquisition of Pax7 expression in hypothalamic progenitor cells. Our studies reveal a requirement for a dual action of BMPs: first, the inhibition of GliA function through Gli3 upregulation; and second, activation of a Smad5-dependent BMP pathway. Previous studies have shown a requirement for spatial antagonism of Shh and BMPs in early CNS patterning; here, we propose that neural pattern elaboration can be achieved through a versatile temporal antagonism between Shh and BMPs.

Key words: Shh, BMP, Neural pattern, Hypothalamus, Gli, Chick