spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

First published online October 10, 2008
doi: 10.1242/10.1242/dev.016931

Development 135, 3481-3489 (2008)
Published by The Company of Biologists 2008
This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Jacob, J.
Right arrow Articles by Gould, A. P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Jacob, J.
Right arrow Articles by Gould, A. P.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Hypothesis

Temporal control of neuronal diversity: common regulatory principles in insects and vertebrates?

John Jacob1,2,*, Cédric Maurange1,* and Alex P. Gould1,*

1 Division of Developmental Neurobiology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK.
2 National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK.

* Authors for correspondence (e-mails: jjacob{at}nimr.mrc.ac.uk; cmauran{at}nimr.mrc.ac.uk; agould{at}nimr.mrc.ac.uk)

SUMMARY

It is well established in species as diverse as insects and mammals that different neuronal and glial subtypes are born at distinct times during central nervous system development. In Drosophila, there is now compelling evidence that individual multipotent neuroblasts express a sequence of progenitor transcription factors which, in turn, regulates the postmitotic transcription factors that specify neuronal/glial temporal identities. Here, we examine the hypothesis that the regulatory principles underlying this mode of temporal specification are shared between insects and mammals, even if some of the factors themselves are not. We also propose a general model for birth-order-dependent neural specification and suggest some experiments to test its validity.


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 J. Neurosci.Home page
M. Baek and R. S. Mann
Lineage and Birth Date Specify Motor Neuron Targeting and Dendritic Architecture in Adult Drosophila
J. Neurosci., May 27, 2009; 29(21): 6904 - 6916.
[Abstract] [Full Text] [PDF]


© The Company of Biologists Ltd 2008