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First published online January 11, 2008
doi: 10.1242/10.1242/dev.000505

Development 135, 411-424 (2008)
Published by The Company of Biologists 2008
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Review

Wnt/Notch signalling and information processing during development

Penelope Hayward, Tibor Kalmar and Alfonso Martinez Arias*

Department of Genetics, University of Cambridge, Cambridge CB2 3EH, UK.

* Author for correspondence (e-mail: ama11{at}hermes.cam.ac.uk)

SUMMARY

The Wnt and Notch signalling pathways represent two major channels of communication used by animal cells to control their identities and behaviour during development. A number of reports indicate that their activities are closely intertwined during embryonic development. Here, we review the evidence for this relationship and suggest that Wnt and Notch (`Wntch') signalling act as components of an integrated device that, rather than defining the fate of a cell, determines the probability that a cell will adopt that fate.


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© The Company of Biologists Ltd 2008