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First published online February 8, 2008
doi: 10.1242/10.1242/dev.016865

Development 135, 789-798 (2008)
Published by The Company of Biologists 2008
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Review

Wnt signaling: an essential regulator of cardiovascular differentiation, morphogenesis and progenitor self-renewal

Ethan David Cohen, Ying Tian and Edward E. Morrisey*

Cardiovascular Institute, Institute for Regenerative Medicine, Departments of Medicine and Cell and Developmental Biology, University of Pennsylvania, Philadelphia, PA 19104, USA.

* Author for correspondence (e-mail: emorrise{at}mail.med.upenn.edu)

SUMMARY

Emerging evidence indicates that Wnt signaling regulates crucial aspects of cardiovascular biology (including cardiac morphogenesis, and the self-renewal and differentiation of cardiac progenitor cells). The ability of Wnt signaling to regulate such diverse aspects of cardiovascular development rests on the multifarious downstream and tangential targets affected by this pathway. Here, we discuss the roles for Wnt signaling in cardiac and vascular development, and focus on the emerging role of Wnt signaling in cardiovascular morphogenesis and progenitor cell self-renewal.




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