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First published online 6 February 2008
doi: 10.1242/dev.012799

Development 135, 1059-1068 (2008)
Published by The Company of Biologists 2008
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Runx1 modulates developmental, but not injury-driven, hair follicle stem cell activation

Karen M. Osorio, Song Eun Lee, David J. McDermitt, Sanjeev K. Waghmare, Ying V. Zhang, Hyun Nyun Woo and Tudorita Tumbar*

Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14850, USA.

* Author for correspondence (e-mail: tt252{at}cornell.edu)

Accepted 3 January 2008

Aml1/Runx1 controls developmental aspects of several tissues, is a master regulator of blood stem cells, and plays a role in leukemia. However, it is unclear whether it functions in tissue stem cells other than blood. Here, we have investigated the role of Runx1 in mouse hair follicle stem cells by conditional ablation in epithelial cells. Runx1 disruption affects hair follicle stem cell activation, but not their maintenance, proliferation or differentiation potential. Adult mutant mice exhibit impaired de novo production of hair shafts and all temporary hair cell lineages, owing to a prolonged quiescent phase of the first hair cycle. The lag of stem cell activity is reversed by skin injury. Our work suggests a degree of functional overlap in Runx1 regulation of blood and hair follicle stem cells at an equivalent time point in the development of these two tissues.

Key words: Runx1/Aml1, Hair follicle, Keratinocyte proliferation, Skin, Stem cell activation, Stemness






© The Company of Biologists Ltd 2008