QUICK SEARCH:   [advanced] Author: Keyword(s):
Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents

First published online 20 March 2008
doi: 10.1242/dev.014977

This Article Figures Only Full Text Full Text (PDF) All Versions of this Article: dev.014977v1 135/9/1575    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Google Scholar Articles by Doe, C. Q. PubMed PubMed Citation Articles by Doe, C. Q.

Neural stem cells: balancing self-renewal with differentiation

Howard Hughes Medical Institute, Institute of Neuroscience, Institute of Molecular Biology, University of Oregon, Eugene, OR, USA.

e-mail: cdoe{at}uoregon.edu

SUMMARY

Stem cells are captivating because they have the potential to make multiple cell types yet maintain their undifferentiated state. Recent studies of Drosophila and mammalian neural stem cells have shed light on how stem cells regulate self-renewal versus differentiation and have revealed the proteins, processes and pathways that all converge to regulate neural progenitor self-renewal. If we can better understand how stem cells balance self-renewal versus differentiation, we will significantly advance our knowledge of embryogenesis, cancer biology and brain evolution, as well as the use of stem cells for therapeutic purposes.

This article has been cited by other articles:

				J. Jacob, C. Maurange, and A. P. Gould Temporal control of neuronal diversity: common regulatory principles in insects and vertebrates? Development, November 1, 2008; 135(21): 3481 - 3489. [Abstract] [Full Text] [PDF]

				J. L. Fish, C. Dehay, H. Kennedy, and W. B. Huttner Making bigger brains-the evolution of neural-progenitor-cell division J. Cell Sci., September 1, 2008; 121(17): 2783 - 2793. [Abstract] [Full Text] [PDF]

				C. Chabu and C. Q. Doe Dap160/intersectin binds and activates aPKC to regulate cell polarity and cell cycle progression Development, August 15, 2008; 135(16): 2739 - 2746. [Abstract] [Full Text] [PDF]