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First published online 26 November 2008
doi: 10.1242/dev.025908

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A new model for random X chromosome inactivation

¹ Department of Genetics and the Carolina Center for the Genome Sciences, and University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
² Curriculum in Toxicology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

^* Author for correspondence (e-mail: trm4{at}med.unc.edu)

SUMMARY

X chromosome inactivation (XCI) reduces the number of actively transcribed X chromosomes to one per diploid set of autosomes, allowing for dosage equality between the sexes. In eutherians, the inactive X chromosome in XX females is randomly selected. The mechanisms for determining both how many X chromosomes are present and which to inactivate are unknown. To understand these mechanisms, researchers have created X chromosome mutations and transgenes. Here, we introduce a new model of X chromosome inactivation that aims to account for the findings in recent studies, to promote a re-interpretation of existing data and to direct future experiments.

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