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First published online 13 May 2009
doi: 10.1242/dev.030718

Development 136, 1977-1986 (2009)
Published by The Company of Biologists 2009
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Myosin II regulates extension, growth and patterning in the mammalian cochlear duct

Norio Yamamoto1, Takayuki Okano1, Xuefei Ma2, Robert S. Adelstein2 and Matthew W. Kelley1,*

1 Section on Developmental Neuroscience, National Institute on Deafness and other Communication Disorders, Bethesda, MD 20892, USA.
2 Laboratory of Molecular Cardiology, Genetics and Developmental Biology Center, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.

* Author for correspondence (e-mail: kelleymt{at}nidcd.nih.gov)

Accepted 6 April 2009

The sensory epithelium of the mammalian cochlea comprises mechanosensory hair cells that are arranged into four ordered rows extending along the length of the cochlear spiral. The factors that regulate the alignment of these rows are unknown. Results presented here demonstrate that cellular patterning within the cochlea, including the formation of ordered rows of hair cells, arises through morphological remodeling that is consistent with the mediolateral component of convergent extension. Non-muscle myosin II is shown to be expressed in a pattern that is consistent with an active role in cellular remodeling within the cochlea, and genetic or pharmacological inhibition of myosin II results in defects in cellular patterning that are consistent with a disruption in convergence and extension. These results identify the first molecule, myosin II, which directly regulates cellular patterning and alignment within the cochlear sensory epithelium. Our results also provide insights into the cellular mechanisms that are required for the formation of highly ordered cellular patterns.

Key words: Hair cell, Organ of Corti, Inner ear, Pillar cell, Mouse


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Converging on convergent extension regulators

Development 2009 136: e1204. [Full Text]  





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