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First published online July 10, 2009
doi: 10.1242/10.1242/dev.032391

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Lighting up mRNA localization in Drosophila oogenesis

Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA.

^* Author for correspondence (e-mail: gavis{at}princeton.edu)

SUMMARY

The asymmetric localization of four maternal mRNAs - gurken, bicoid, oskar and nanos - in the Drosophila oocyte is essential for the development of the embryonic body axes. Fluorescent imaging methods are now being used to visualize these mRNAs in living tissue, allowing dynamic analysis of their behaviors throughout the process of localization. This review summarizes recent findings from such studies that provide new insight into the elaborate cellular mechanisms that are used to transport mRNAs to different regions of the oocyte and to maintain their localized distributions during oogenesis.

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