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First published online 15 July 2009
doi: 10.1242/dev.037911

Development 136, 2689-2693 (2009)
Published by The Company of Biologists 2009
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Research Report

The Tbx20 homologs midline and H15 specify ventral fate in the Drosophila melanogaster leg

Pia C. Svendsen1, Ann Formaz-Preston1, Sandra M. Leal2 and William J. Brook1,*

1 Genes and Development Research Group, Department of Biochemistry and Molecular Biology, Department of Medical Genetics, University of Calgary, 3330 Hospital Drive NW, Calgary AB, Canada T2N 4N1.
2 Department of Biological Sciences, University of Southern Mississippi, 118 College Drive #5018, Hattiesburg, MS 39406-0001, USA.

* Author for correspondence (e-mail: brook{at}ucalgary.ca)

Accepted 12 June 2009

SUMMARY

Regional fates in the developing limbs of Drosophila melanogaster are controlled by selector gene transcription factors. Ventral fate in the fly leg is specified by the expression of the ligand Wingless. We present evidence that midline and H15, members of the Tbx20 class of T-box transcription factors, are key mediators of the Wingless signal in the formation of the ventral region of the fly leg. midline and H15 are restricted to identical ventral domains of expression through activation by Wingless and repression by the dorsal signal Decapentaplegic. midline and H15 function redundantly and cell autonomously in the formation of ventral-specific structures. Conversely, midline is sufficient to induce ventral fate. Finally, the induction of ectopic ventral fate by mid is compromised when Wingless signaling is attenuated, suggesting that Wingless acts both upstream and in parallel with midline/H15 to specify ventral fate. Based on these results, we propose that midline and H15 may be considered as the selector genes for ventral leg fate.

Key words: T-box transcription factor, Limb development, Pattern formation, Selector gene


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Development 2009 136: e1601. [Full Text]  





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