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First published online September 7, 2009
doi: 10.1242/10.1242/dev.040451

Development 136, 3289-3299 (2009)
Published by The Company of Biologists 2009
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A directional Wnt/β-catenin-Sox2-proneural pathway regulates the transition from proliferation to differentiation in the Xenopus retina

Michalis Agathocleous1, Ilina Iordanova1, Minde I. Willardsen2, Xiao Yan Xue1, Monica L. Vetter2,*,{dagger}, William A. Harris1,*,{dagger} and Kathryn B. Moore2

1 Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge CB2 3DY, UK.
2 Department of Neurobiology and Anatomy, University of Utah, Salt Lake City, UT 84132, USA.

{dagger} Authors for correspondence (monica.vetter{at}neuro.utah.edu; harris{at}mole.bio.cam.ac.uk)

Accepted 4 August 2009

Progenitor cells in the central nervous system must leave the cell cycle to become neurons and glia, but the signals that coordinate this transition remain largely unknown. We previously found that Wnt signaling, acting through Sox2, promotes neural competence in the Xenopus retina by activating proneural gene expression. We now report that Wnt and Sox2 inhibit neural differentiation through Notch activation. Independently of Sox2, Wnt stimulates retinal progenitor proliferation and this, when combined with the block on differentiation, maintains retinal progenitor fates. Feedback inhibition by Sox2 on Wnt signaling and by the proneural transcription factors on Sox2 mean that each element of the core pathway activates the next element and inhibits the previous one, providing a directional network that ensures retinal cells make the transition from progenitors to neurons and glia.

Key words: Sox, Neuron, Progenitor, Proneural, Retina, Wnt, Xenopus


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Development 2009 136: e1904. [Full Text]  



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Home page
 J. Cell Sci.Home page
M. Agathocleous, I. Iordanova, M. I. Willardsen, X. Y. Xue, M. L. Vetter, W. A. Harris, and K. B. Moore
A directional Wnt/{beta}-catenin-Sox2-proneural pathway regulates the transition from proliferation to differentiation in the Xenopus retina
J. Cell Sci., October 1, 2009; 122(19): e1906 - e1906.
[Full Text]


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