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First published online December 22, 2008
doi: 10.1242/10.1242/dev.024158

Development 136, 179-190 (2009)
Published by The Company of Biologists 2009
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Review

Growing models of vertebrate limb development

Matthew Towers and Cheryll Tickle*

Department of Biology and Biochemistry, University of Bath, Bath BA2 7AY, UK

* Author for correspondence (e-mail: cat24{at}bath.ac.uk)

SUMMARY

The developing limb has been a very influential system for studying pattern formation in vertebrates. In the past, classical embryological models have explained how patterned structures are generated along the two principal axes of the limb: the proximodistal (shoulder to finger) and anteroposterior (thumb to little finger) axes. Over time, the genetic and molecular attributes of these patterning models have been discovered, while the role of growth in the patterning process has been only recently highlighted. In this review, we discuss these recent findings and propose how the various models of limb patterning can be reconciled.


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© The Company of Biologists Ltd 2009