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First published online October 23, 2009
doi: 10.1242/10.1242/dev.038109

Development 136, 3801-3810 (2009)
Published by The Company of Biologists 2009
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Wnt-Ror signaling to SIA and SIB neurons directs anterior axon guidance and nerve ring placement in C. elegans

Jason R. Kennerdell1,2, Richard D. Fetter3 and Cornelia I. Bargmann1,*

1 Howard Hughes Medical Institute, Laboratory of Neural Circuits and Behavior, The Rockefeller University, New York, NY 10065, USA.
2 Program in Biological Sciences, The University of California, San Francisco, CA 94143, USA.
3 Howard Hughes Medical Institute, Janelia Farm Research Campus, Ashburn, VA 20147, USA.

* Author for correspondence (cori{at}mail.rockefeller.edu)

Accepted 16 September 2009

Wnt signaling through Frizzled proteins guides posterior cells and axons in C. elegans into different spatial domains. Here we demonstrate an essential role for Wnt signaling through Ror tyrosine kinase homologs in the most prominent anterior neuropil, the nerve ring. A genetic screen uncovered cwn-2, the C. elegans homolog of Wnt5, as a regulator of nerve ring placement. In cwn-2 mutants, all neuronal structures in and around the nerve ring are shifted to an abnormal anterior position. cwn-2 is required at the time of nerve ring formation; it is expressed by cells posterior of the nerve ring, but its precise site of expression is not critical for its function. In nerve ring development, cwn-2 acts primarily through the Wnt receptor CAM-1 (Ror), together with the Frizzled protein MIG-1, with parallel roles for the Frizzled protein CFZ-2. The identification of CAM-1 as a CWN-2 receptor contrasts with CAM-1 action as a non-receptor in other C. elegans Wnt pathways. Cell-specific rescue of cam-1 and cell ablation experiments reveal a crucial role for the SIA and SIB neurons in positioning the nerve ring, linking Wnt signaling to specific cells that organize the anterior nervous system.

Key words: Axon guidance, C. elegans, Neuronal development, Wnt signaling


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J. R. Kennerdell, R. D. Fetter, and C. I. Bargmann
Wnt-Ror signaling to SIA and SIB neurons directs anterior axon guidance and nerve ring placement in C. elegans
J. Cell Sci., November 15, 2009; 122(22): e2207 - e2207.
[Full Text]


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