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First published online November 11, 2009
doi: 10.1242/10.1242/dev.040089

Development 136, 3875-3880 (2009)
Published by The Company of Biologists 2009
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Hedgehog, but not Odd skipped, induces segmental grooves in the Drosophila epidermis

Shai Mulinari and Udo Häcker*

Department of Experimental Medical Science and Lund Strategic Research Center for Stem Cell Biology and Cell Therapy, Lund University, BMC B13, 22184 Lund, Sweden

* Author for correspondence (udo.hacker{at}med.lu.se)

Accepted September 26, 2009

The formation of segmental grooves during mid embryogenesis in the Drosophila epidermis depends on the specification of a single row of groove cells posteriorly adjacent to cells that express the Hedgehog signal. However, the mechanism of groove formation and the role of the parasegmental organizer, which consists of adjacent rows of hedgehog- and wingless-expressing cells, are not well understood. We report that although groove cells originate from a population of Odd skipped-expressing cells, this pair-rule transcription factor is not required for their specification. We further find that Hedgehog is sufficient to specify groove fate in cells of different origin as late as stage 10, suggesting that Hedgehog induces groove cell fate rather than maintaining a pre-established state. Wingless activity is continuously required in the posterior part of parasegments to antagonize segmental groove formation. Our data support an instructive role for the Wingless/Hedgehog organizer in cellular patterning.

Key words: Drosophila, Hedgehog, Wingless, Odd skipped, Patterning, Segmental grooves


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© The Company of Biologists Ltd 2009