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First published online November 11, 2009
doi: 10.1242/10.1242/dev.035477

Development 136, 3907-3915 (2009)
Published by The Company of Biologists 2009
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The C. elegans tailless/Tlx homolog nhr-67 regulates a stage-specific program of linker cell migration in male gonadogenesis

Mihoko Kato and Paul W. Sternberg*

HHMI and Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA

* Author for correspondence (pws{at}caltech.edu)

Accepted September 22, 2009

Cell migration is a common event during organogenesis, yet little is known about how migration is temporally coordinated with organ development. We are investigating stage-specific programs of cell migration using the linker cell (LC), a migratory cell crucial for male gonadogenesis of C. elegans. During the L3 and L4 larval stages of wild-type males, the LC undergoes changes in its position along the migratory route, in transcriptional regulation of the unc-5 netrin receptor and zmp-1 zinc matrix metalloprotease, and in cell morphology. We have identified the tailless homolog nhr-67 as a cell-autonomous, stage-specific regulator of timing in LC migration programs. In nhr-67-deficient animals, each of the L3 and L4 stage changes is either severely delayed or never occurs, yet LC development before the early L3 stage or after the mid-L4 stage occurs with normal timing. We propose that there is a basal migration program utilized throughout LC migration that is modified by stage-specific regulators such as nhr-67.

Key words: C. elegans males, Gonadogenesis, Cell migration, nhr-67/tailless, Timing


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© The Company of Biologists Ltd 2009