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First published online 28 January 2009
doi: 10.1242/dev.027995

Development 136, 781-789 (2009)
Published by The Company of Biologists 2009
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Tcf3 inhibits spinal cord neurogenesis by regulating sox4a expression

Suzanna L. Gribble1,*,{dagger}, Hyung-Seok Kim1,*, Jennifer Bonner1,{ddagger}, Xu Wang1 and Richard I. Dorsky1,2,¶

1 Department of Neurobiology and Anatomy, University of Utah School of Medicine, Salt Lake City, UT 84132, USA.
2 The Brain Institute, University of Utah School of Medicine, Salt Lake City, UT 84132, USA.

Author for correspondence (e-mail: richard.dorsky{at}neuro.utah.edu)

Accepted 19 December 2008

The Lef/Tcf factor Tcf3 is expressed throughout the developing vertebrate central nervous system (CNS), but its function and transcriptional targets are uncharacterized. Tcf3 is thought to mediate canonical Wnt signaling, which functions in CNS patterning, proliferation and neurogenesis. In this study, we examine Tcf3 function in the zebrafish spinal cord, and find that this factor does not play a general role in patterning, but is required for the proper expression of Dbx genes in intermediate progenitors. In addition, we show that Tcf3 is required to inhibit premature neurogenesis in spinal progenitors by repressing sox4a, a known mediator of spinal neurogenesis. Both of these functions are mediated by Tcf3 independently of canonical Wnt signaling. Together, our data indicate a novel mechanism for the regulation of neurogenesis by Tcf3-mediated repression.

Key words: Zebrafish, Tcf3, Spinal progenitors, Wnt


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