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First published online 11 February 2009
doi: 10.1242/dev.029868

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Requirement for Sun1 in the expression of meiotic reproductive genes and piRNA

¹ Molecular Virology Section, Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
² Institute of Cellular and System Medicine, National Health Research Institutes, Zhunan 35053, Taiwan.
³ Infectious Disease Pathogenesis Section, Comparative Medicine Branch, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
⁴ Microarray Research Facility, Genomic Technologies Section, Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

^* Author for correspondence (e-mail: kj7e{at}nih.gov)

Accepted 16 January 2009

The inner nuclear envelope (NE) proteins interact with the nuclear lamina and participate in the architectural compartmentalization of chromosomes. The association of NE proteins with DNA contributes to the spatial rearrangement of chromosomes and their gene expression. Sun1 is an inner nuclear membrane (INM) protein that locates to telomeres and anchors chromosome movement in the prophase of meiosis. Here, we have created Sun1^–/– mice and have found that these mice are born and grow normally but are reproductively infertile. Detailed molecular analyses showed that Sun1^–/– P14 testes are repressed for the expression of reproductive genes and have no detectable piRNA. These findings raise a heretofore unrecognized role of Sun1 in the selective gene expression of coding and non-coding RNAs needed for gametogenesis.

Key words: Sun1, Sad1, Unc84, Nuclear envelope, Gametogenesis, piRNA, Mouse

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