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First published online March 20, 2009
doi: 10.1242/10.1242/dev.022418

Development 136, 1223-1229 (2009)
Published by The Company of Biologists 2009
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Review

Chemokine signaling in embryonic cell migration: a fisheye view

Erez Raz* and Harsha Mahabaleshwar

Institute of Cell Biology, ZMBE, University of Münster, Von-Esmarch-Straße 56, 48149 Münster, Germany.

* Author for correspondence (e-mail: erez.raz{at}uni-muenster.de)

SUMMARY

Chemokines and their receptors were discovered about twenty years ago as mediators of leukocyte traffic. Over the past decade, functional studies of these molecules have revealed their importance for cell migration processes during embryogenesis, which, in addition to providing mechanistic insights into embryonic development, could complement information about chemokine function in the immune system. Here, we review the roles of the chemokine stromal cell-derived factor 1 (SDF-1/CXCL12) and its receptor CXCR4 during zebrafish and mouse embryonic development, and discuss their function in regulating the interactions of cells with their extracellular environment, in directing their migration, and in maintaining their location.


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