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First published online 4 March 2009
doi: 10.1242/dev.032508

Development 136, 1231-1240 (2009)
Published by The Company of Biologists 2009
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Lgl2 and E-cadherin act antagonistically to regulate hemidesmosome formation during epidermal development in zebrafish

Mahendra Sonawane*, Hans Martin-Maischein, Heinz Schwarz and Christiane Nüsslein-Volhard

Max-Planck Institut für Entwicklungsbiologie, Department of Genetics, Spemannstraße 35, Tuebingen, D-72076, Germany.

* Author for correspondence (e-mail: mahendra.sonawane{at}tuebingen.mpg.de)

Accepted 9 February 2009

The integrity and homeostasis of the vertebrate epidermis depend on various cellular junctions. How these junctions are assembled during development and how their number is regulated remain largely unclear. Here, we address these issues by analysing the function of Lgl2, E-cadherin and atypical Protein kinase C (aPKC) in the formation of hemidesmosomes in the developing basal epidermis of zebrafish larvae. Previously, we have shown that a mutation in lgl2 (penner) prevents the formation of hemidesmosomes. Here we show that Lgl2 function is essential for mediating the targeting of Integrin alpha 6 (Itga6), a hemidesmosomal component, to the plasma membrane of basal epidermal cells. In addition, we show that whereas aPKC{lambda} seems dispensable for the localisation of Itga6 during hemidesmosome formation, knockdown of E-cadherin function leads to an Lgl2-dependent increase in the localisation of Itga6. Thus, Lgl2 and E-cadherin act antagonistically to control the localisation of Itga6 during the formation of hemidesmosomes in the developing epidermis.

Key words: Lgl2 (Llgl2), E-cadherin (Cadherin 1), Hemidesmosome formation, Epidermis, Zebrafish


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[Abstract] [Full Text] [PDF]


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