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First published online 11 March 2009
doi: 10.1242/dev.026922

Development 136, 1305-1315 (2009)
Published by The Company of Biologists 2009
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Control of convergent yolk syncytial layer nuclear movement in zebrafish

Lara Carvalho1, Jan Stühmer1, Justin S. Bois1,2, Yannis Kalaidzidis1, Virginie Lecaudey3 and Carl-Philipp Heisenberg1,*

1 Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstr. 108, 01307 Dresden, Germany.
2 Max-Planck-Institute for the Physics of Complex Systems, Nöthnitzer Str. 38, 01187 Dresden, Germany.
3 European Molecular Biology Laboratory, Cell Biology and Biophysics Department, Meyerhofstr. 1, 69126 Heidelberg, Germany.

* Author for correspondence (e-mail: heisenberg{at}mpi-cbg.de)

Accepted 11 February 2009

Nuclear movements play an essential role in metazoan development. Although the intracellular transport mechanisms underlying nuclear movements have been studied in detail, relatively little is known about signals from surrounding cells and tissues controlling these movements. Here, we show that, in gastrulating zebrafish embryos, convergence movements of nuclei within the yolk syncytial layer (YSL) are guided by mesoderm and endoderm progenitors migrating along the surface of the yolk towards the dorsal side of the developing gastrula. Progenitor cells direct the convergence movements of internal yolk syncytial nuclei (iYSN) by modulating cortical flow within the YSL in which the iYSN are entrained. The effect of mesoderm and endoderm progenitors on the convergence movement of iYSN depends on the expression of E-cadherin, indicating that adhesive contact between the cells and the YSL is required for the mesendoderm-modulated YSL cortical flow mediating nuclear convergence. In summary, our data reveal a crucial function for cortical flow in the coordination of syncytial nuclear movements with surrounding cells and tissues during zebrafish gastrulation.

Key words: Gastrulation, Zebrafish, Nuclear movements, Yolk syncytial layer, Cortical flow


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