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J Embryol Exp Morphol 34, 589-607 (1975)
Published by The Company of Biologists 1975
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Cell proliferation in the developing wing-bud of normal and talpid3 mutant chick embryos

D. A. Ede1, O. P. Flint1 and P. Teague2

Department of Zoology, University of Glasgow and the A.R.C. Poultry Research Centre, Edinburgh

1 Authors' address: Developmental Biology Building, 124 Observatory Road, Glasgow G12 9LU, U.K.

2 Author's address: A.R.C. Poultry Research Centre, King's Buildings, West Mains Road, Edinburgh, U.K.

Received for publication 5 February 1975. Revision received 20 June 1975.

SUMMARY

Previous measurements on mitotic division rate or cell cycle time have been made on samples from a few discrete limb regions or by continuous sampling, but only down a unidimensional limb axis, disregarding morphological discontinuities such as the presence or absence of cartilage. This study presents a new analysis on normal and talpid3 mutant chick embryos, measuring mitotic rate and also cell density through the central proximo-distal axis and at the limb periphery, taking into account the development of cartilage regions. Differentiation of cartilage is correlated with a marked drop in mitotic rate, accounting for a proximo-distal gradient of mitosis in central counts which was not observed at the limb periphery. Talpid3 limbs at an early stage show a central mitotic gradient, but the reverse of that observed in normal limbs.


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© The Company of Biologists Ltd 1975