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Selective Inhibition of Cleavage in Different Regions of the Frog Egg by Sulphydryl Inhibitors

Department of Zoology, Columbia University, New York City

¹ Author's address: Department of Zoology, Columbia University, New York 27, N.Y., U.S.A.

Received for publication 27 June 1955.

SUMMARY

That the materials for protein synthesis in the frog egg must come from yolk is indicated by the constancy of total nitrogen during development (Gregg & Ballentine, 1946) and the fact that the egg can develop with no outside source of organic or inorganic materials. When and where in the developing egg new proteins arise, and what are the mechanisms which control the rate and direct the specificity of such syntheses, are problems which are beginning to occupy increasing numbers investigators using several methods of attack—immunological, enzymological, electrophoretic, and incorporation of labelled amino acids, for example.

Brachet (1940), using histochemical methods, described a change in the distribution of sulphydryl proteins coincident with grey crescent formation. In the newly-laid egg of Triton or Pleurodeles Brachet found the sulphydryl proteins to be restricted to a small spot centred about the maturation figure near the animal pole. This picture changed during the first few hours after fertilization.

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